Cigarette and tobacco-related diseases are major global health concerns, contributing to 35% of all cancer deaths. This study was aimed to assess the impact of cigarette smoke on Wistar rats. Twenty male rats of varying ages (2, 4, and 7 months) and similar weights (106-156g) were divided into four groups. Groups B, C, and D were exposed to smoke from 1, 3, and 5 cigarettes (Benson and Hedges), respectively for 30 minutes per session, five days a week and over eight weeks. Group A served as the control with no smoke exposure. Blood samples were collected and the liver, kidneys, and lungs were examined histologically. Blood analysis showed significant increases in red and white blood cell counts, creatinine, urea, aspartate transferase (AST), and alanine transferase (ALT) levels in the exposed groups compared to the control. Histological findings revealed tissue damage, including haemorrhages, kidney degeneration, liver necrosis, and lung congestion. It can be concluded from the study that, cigarette smoke exposure causes significant damage and dysfunction to major organs and blood parameters in Wistar rats, highlighting its toxicity to the body.