Intestinal Parasitic Infections (IPIs) are a major global health concern. Although WHO recommends mass administration of medicines (albendazole or mebendazole) to control soil-transmitted helminths in children, foster children are often overlooked. This study investigated the prevalence and risk factors of intestinal parasites among children in orphanages in Calabar, Nigeria. A cross-sectional study was conducted among 260 children in registered orphanages from March to August 2024. Data on socio-demographics and hygiene practices were collected via structured questionnaires and interviews. Stool samples were analysed using standard methods. Data were analysed with descriptive statistics, Chi square, odds ratio and binomial logistic regression. The overall prevalence of infection was 23.5% (n=61), higher among females (24.6%) and children aged 10 years and above (33.6%, p=0.001). Ascaris lumbricoides (11.5%) and hookworm (6.5%) were the most common parasites. Entamoeba histolytica was the most frequently detected protozoan parasite (3.5%, n=20). Poor hand washing before eating (OR=4.53, p<0.0001) and after toilet use (OR=4.96, p<0.0001) increased infection risk. Health education and targeted control programmes are essential for reducing IPIs in children resident in institutionalised homes.